The triumph will put the 19-year-old Serb, who reached this year's French Open final and Wimbledon semi-finals, fourth in the rankings.
Amelie Mauresmo's Wimbledon reign ended in a bizarre fourth round encounter when she was upset by the Czech teenager.
Top seed Agnieszka Radwanska put on a dominant performance against double defending champion Petra Kvitova to ease into the final of the Connecticut Open with a 6-1, 6-1 triumph on Friday.
Captain Steven Gerrard scored twice to rescue Liverpool from FA Cup embarrassment and lead them into the fourth round after a tricky 2-1 win at fourth tier AFC Wimbledon on Monday.
Grigor Dimitrov reached his first grand slam quarter-final in over two years on Monday by defeating an injury-hampered Denis Istomin 2-6, 7-6(2), 6-2, 6-1 to end the Uzbek wildcard's fairytale run at the Australian Open.
After all the shocks and spills of the opening week, top seed Serena Williams remained impregnable as she unleashed her full arsenal to move almost effortlessly into the last 16 at Wimbledon on Saturday. A crushing 6-2, 6-0 win over Japanese veteran Kimiko Date-Krumm offered a reminder that while her closest rivals in the women's game are often vulnerable to upsets, she is an immovable object at the top of the tree.
Stan Wawrinka outlasted Frances Tiafoe over three sets to set up an all-home quarter-final against compatriot and fellow veteran Roger Federer at the Swiss Indoors on Thursday. The 34-year-old Waewrinka, who won 6-3, 3-6, 7-5, will attempt to beat Federer for only the fourth time when they meet for their 27th clash on Friday in a dream tie for the Basel crowd.
Both reached the semi-finals of the Montreal Masters, beating Lleyton Hewitt and Frank Dancevic respectively.
It was the Russian's first competitive match since she withdrew from the St Petersburg Open in January.
The 20-year-old, free of a shoulder injury that forced her out of qualifying for last week's Hobart tournament, won her first match at the Australian Open at her fourth attempt with a 6-4, 7-5 victory over Germany's Annika Beck.
The Frenchwoman came within a point of dumping world number one Ana Ivanovic out of Wimbledon in the second round but found the Gods were not on her side.
Less than a month after her run to the Wimbledon final, where she lost to Spain's Garbine Muguruza, 37-year-old Williams again had to turn back time against a young challenger.
The world No 32 cited a left wrist injury as the reason for her withdrawal.
2016 is at the halfway stage and the year has already seen some stunning sporting wins, underdogs emerging triumphant on the biggest stages of them all.
The world number one overcame a rocky start to beat the Frenchman in the final of the Toronto Masters.
Rafael Nadal was upset by Tomas Berdych and Roger Federer survived a scare in the Toronto Masters third round.
The Indian ace beat Katarina Srebotnik 6-3, 7-6 to set up a third round clash with Elena Dementieva.
An Australian Open electrified by the revivals of seasoned champions will bathe in the warm glow of nostalgia on Saturday when the Williams sisters contest the women's final at Rod Laver Arena.
Dinara Safina beat Maria Sharapova 7-5, 2-6, 7-5 in the fourth round of the French Open
Former Wimbledon champion Marion Bartoli just wants to enjoy herself and play big matches when she returns to competitive tennis in March after more than four years in retirement.
Croatian beanpole Ivo Karlovic upset top-seeded compatriot Ivan Ljubicic to reach the quarter-finals of the grasscourt Nottingham Open on Wednesday.
Novak Djokovic continued his Wimbledon preparations by beating American Donald Young 6-2, 7-6(9) on Thursday to reach the semi-finals of the Aegon International tournament at Eastbourne.
The former world No. 4 confirmed participation for the February 7-12 WTA event.
Nadal, who got a first-round bye, defeated Richard Gasquet 6-3, 6-4 to advance.
It was Novak Djokovic's first match this year after his Australian Open hopes were dashed when he was deported following an 11-day saga revolving around his decision not to have a COVID-19 vaccination.
Frenchman Benoit lost his temper in the third game of the second set when top seed Tsitsipas halted the match to attend to a broken shoe lace.
The Indian ace was beaten in straight sets by Japan's Akiko Morigami.
The Indian teenager will take on seventh seed Anna-Lena Groenefeld at the USD 170,000 Cincinnati Open.
A summary of Thursday's play at the US Open.
The former made it to the second round in the girls' doubles while the latter couldn't.
A summary of Wednesday's action at the US Open.
A look at the records of Austria's Dominic Thiem and Spain's Rafael Nadal before their title clash at the French Open on Sunday.
Images from Day 1 of the French Open matches played at Roland Garros on Sunday
The Indian girl and Alisa Kleybanova defeated Emma Laine of Finland and Nadja Pavic of Crotia 6-1, 6-2 in the quarters.